University of Guilan Aquatic Animals Nutrition 2980-8499 5 2 2020 02 20 Effects of supplementing diet with the alcoholic and nanoencapsulated nettle (Urtica dioica) extracts on growth performance and hematological indices of rainbow trout (Oncorhynchus mykiss) Effects of supplementing diet with the alcoholic and nanoencapsulated nettle (Urtica dioica) extracts on growth performance and hematological indices of rainbow trout (Oncorhynchus mykiss) 101 113 4223 10.22124/janb.2020.16465.1090 FA Abbas Graily Afra Fisheries Department, Sari University of Agricultural Sciences and Natural Resources, Sari, Mazandaran, Iran Masoud Darroudi Masoud Darroudi Hossein Ouraji Fisheries Department, Sari University of Agricultural Sciences and Natural Resources, Sari, Mazandaran, Iran Abdolsamad Keramat Fisheries Department, Sari University of Agricultural Sciences and Natural Resources, Sari, Mazandaran, Iran Reza Safari Caspian Sea Ecology Research Center (CSERC), Sari, Mazandaran, Iran Journal Article 2019 03 03 This study was carried out to evaluate the effects of alcoholic and nanoencapsulated nettle (<em>Urtica</em> <em>dioica</em>) extracts on growth performance and hematological indices of rainbow trout (<em>Oncorhynchus</em> <em>mykiss</em>). A total of 225 rainbow trout with an average initial weight of 23 ± 0.16 g (mean ± standard deviation) were fed with five diets supplemented with 0% (control group), 1% alcoholic extract (A1), 2% alcoholic extract (A2), 1% nanoparticle extract (N1) and 2% nanoparticle extract (N2) for 8 weeks. The treatments A2 and N2 showed significantly higher final weight and specific growth rate compared to the control as well as  A1 and N1. The experimental diets exhibited significant effects on some hematological indices, such that the highest levels of white blood cells, lymphocytes, total protein, albumin and also lysozyme activity were observed in A2 and N2. These results suggested that supplementing diet with the alcoholic and nanoencapsulated nettle extracts enhance immunity, and promote fish growth. This study was carried out to evaluate the effects of alcoholic and nanoencapsulated nettle (<em>Urtica</em> <em>dioica</em>) extracts on growth performance and hematological indices of rainbow trout (<em>Oncorhynchus</em> <em>mykiss</em>). A total of 225 rainbow trout with an average initial weight of 23 ± 0.16 g (mean ± standard deviation) were fed with five diets supplemented with 0% (control group), 1% alcoholic extract (A1), 2% alcoholic extract (A2), 1% nanoparticle extract (N1) and 2% nanoparticle extract (N2) for 8 weeks. The treatments A2 and N2 showed significantly higher final weight and specific growth rate compared to the control as well as  A1 and N1. The experimental diets exhibited significant effects on some hematological indices, such that the highest levels of white blood cells, lymphocytes, total protein, albumin and also lysozyme activity were observed in A2 and N2. These results suggested that supplementing diet with the alcoholic and nanoencapsulated nettle extracts enhance immunity, and promote fish growth. https://janb.guilan.ac.ir/article_4223_b1d31f177e82a8345da20b12485d7a78.pdf